When did AIRE start?
The Register of Italians living abroad (A. I. R. E. Law No. October 27, 1988 and contains the data of Italian citizens living abroad for a period of over twelve months. Yes, AIRE registration is mandatory for all Italian citizens who move abroad for a period exceeding 12 months. This requirement is established by Law No. Despite this, many people neglect this obligation, often due to a lack of information or because they underestimate the importance of the registry.Italian citizens who moved abroad are required to register with the AIRE of the Italian Consulate that has jurisdiction over the foreign state/country where they reside, within 90 days from the day of their arrival (Law no.Registering in AIRE is a duty, as well as a right, of each Italian citizen, and it is FREE.
How does AIRE work?
AIRE is a transcription factor expressed in the medulla (inner part) of the thymus. It is part of the mechanism which eliminates self-reactive T cells that would cause autoimmune disease. It exposes T cells to normal, healthy proteins from all parts of the body, and T cells that react to those proteins are destroyed. The AIRE gene provides instructions for making a protein called the autoimmune regulator. This protein is active primarily in the thymus, which is an organ located behind the breastbone that plays an important role in immune system function.Autoimmune regulator (AIRE) has a well-known role in preventing autoimmunity through upregulation of tissue-specific antigen (TSA) expression in medullary thymic epithelial cells (mTECs).