How do I get from SF to San Diego?
The cheapest way to get from San Francisco to San Diego is to bus which costs $60 – $150 and takes 13h 16m. What is the fastest way to get from San Francisco to San Diego? The fastest way to get from San Francisco to San Diego is to fly which takes 3h 23m and costs $65 – $600. One of the ultimate road trip destinations has to be the Pacific Coast Highway, or Highway One, which spans 600 miles of the California coastline from San Diego in the south to San Francisco in the north.